Slug slime inspires a new type of surgical glue

For a glue that holds up inside the body, turn to the humble slug, Arion subfuscus. A new super-sticky material mimics slug slime’s ability to stick on slick wet surfaces and could lead to more effective medical adhesives.

The material has two parts: a sticky layer that attaches to a surface, and a shock-absorbing layer that reduces strain. That makes the adhesive less likely to snap off.

Researchers tested the material as a surgical adhesive in a number of different scenarios: It stuck to pig skin and liver. It latched on to a beating pig’s heart, even when the surface was coated in blood. It sealed up a heart defect, preventing liquid from leaking even when the organ was inflated and deflated tens of thousands of times. And it was less toxic in the body than a commonly used commercialized tissue adhesive, researchers report July 28 in Science.

The researchers hope the material could someday be used in surgical procedures in place of invasive sutures and staples.

Why midsize animals are the fastest

Speed has its limits — on the open road and the Serengeti. Midsize animals tend to be the speedsters, even though, in theory, the biggest animals should be the fastest. A new analysis that relates speed and body size in 474 species shows that the pattern holds for animals whether they run, fly or swim (see graphs below) and suggests how size becomes a liability.

This relationship between speed and size has long stumped scientists. Big animals have longer legs or flippers to get from point A to point B. And bigger bodies have higher metabolic rates and more fast-twitch muscle cells, needed to convert chemical energy into mechanical energy and rapidly accelerate. So, why aren’t wildebeests faster than cheetahs?
The make-or-break factor is the time it takes an animal to accelerate to its top theoretical speed, an upper limit based on mass and metabolic rate, researchers report July 17 in Nature Ecology & Evolution. Fast-twitch muscle cells provide the power for acceleration but tire quickly. When an animal gets too big, it takes too long to accelerate, and these cells use up their energy before hitting top speeds. More modestly built critters need less time to accelerate to those speeds.

The researchers gathered speed and size data from past lab and field studies. The animals (some shown as icons in the slideshow below) ranged in mass from 30-microgram Spanish mites to a blue whale weighing 108 metric tons.

Polluted water: It’s where sea snakes wear black

Maybe it’s more than reptile fashion. The high percentage of citified sea snakes wearing black might be a sign that pollution is an evolutionary force.

Off the coasts of Australia and New Caledonia, some turtle-headed sea snakes (Emydocephalus annulatus) sport pale bands on their dark skins. Others go all black. In 15 places surveyed, the all-black form was more likely to predominate in waters near cities, military sites or industrial zones than along reefs near less built-up coastlines, says evolutionary ecologist Rick Shine of the University of Sydney.
That trend plus some analysis of trace elements in snakes’ skin suggests that the abundant dark forms could turn out to be an example of industrial melanism, Shine and his colleagues propose August 10 in Current Biology.

The most famous example of this evolutionary phenomenon comes from a dark form of peppered moth that overtook pale populations in 19th century England (SN: 6/25/16, p. 6). Dark wings created better camouflage from hungry birds in the grimy industrializing landscape.
Shine doesn’t think the sea snakes are going for camouflage, though. Instead, the snakes could be more like the dark-feathered pigeons of Paris. The melanin that gives that city’s feral birds their urban chic also does a great job of binding traces of toxic metals such as zinc, explains evolutionary ecologist Marion Chatelain of the University of Warsaw. When birds molt, getting rid of darker feathers lets them unload more of the unhealthful urban pollutants, she and colleagues have reported.
This could explain why marine biologist and study coauthor Claire Goiran has so many dark turtle-headed sea snakes in a lagoon not far from her campus, the University of New Caledonia in Nouméa. Earlier studies had found only downsides to dark coloration: Seaweed spores preferentially settle on dark snakes and sprout fuzz that can cut swimming speed by 20 percent and cause a snake to shed its skin more often than normal.
To test a scenario of industrial melanism, or darkening due to pollution, the researchers collected data on skin colors for a total of about 1,450 snakes, both live and museum specimens, from 15 sites in New Caledonia and Australia. Higher percentages of all-dark snakes wriggled around the nine polluted sites surveyed. At one, a remote Australian reef that the military had long used as a bombing range, all 13 specimens were dark.

To test shed skins for trace metals, Goiran and Shine enlisted Paco Bustamante of the University of La Rochelle in France, who studies trace metal contamination in marine life.

Researchers managed to collect sloughed skins from 17 turtle-headed snakes, which inconveniently shed their skin underwater. To compare light and dark patches, the scientists turned to two local species of sea kraits, which have banded skin and visit land to shed it.
Overall, skins held concentrations of trace elements higher than those that can cause health problems in birds and mammals, the researchers report. In the krait skins, dark zones had slightly more of some contaminants, such as zinc and arsenic, than the pale bluish-white bands did.

The idea that polluted water favors melanized sea snakes “is a reasonable hypothesis based on what we know,” Chatelain says. Definitive tests will require more data and different approaches. Genetic testing, for example, would clarify whether dark populations arose instead from small groups of pioneers that happened to have a lot of black snakes.

That testing could be a long way off. Sea snakes are evolutionary cousins of cobras and mambas, and some of the species swimming around Australia and New Caledonia are “bowel-looseningly large,” Shine says. At least the little turtle-headed ones, which eat eggs of small reef fishes, have venom glands that have atrophied and “probably couldn’t fit a human finger in their mouths.” But until someone figures out how to keep them alive in captivity for more than a few days, Shine isn’t expecting definitive genetics.

Some secrets of China’s terra-cotta army are baked in the clay

China’s first emperor broke the mold when he had himself buried with a terra-cotta army. Now insight into the careful crafting of those soldiers is coming from the clays used to build them. Custom clay pastes were mixed at a clay-making center and then distributed to specialized workshops that cranked out thousands of the life-size figures, new research suggests.

Roughly 700,000 craftsmen and laborers built Emperor Qin Shihuang’s palatial mausoleum in east-central China between 247 B.C. and 210 B.C. A portion of those workers gathered clay from nearby deposits and prepared it in at least three forms, researchers propose in the August Antiquity. On-site or nearby workshops used different signature clay recipes for terra-cotta warriors, parts of mostly bronze waterfowl figures and paving bricks for pits in which the soldiers originally stood.
Around 7,000 ceramic foot soldiers, generals and horses — equipped with a variety of bronze weapons — make up the army, which was accidentally discovered in 1974 by farmers digging a well. The emperor would have regarded the ceramic statues as a magic army that would protect him as he ruled in the afterlife, many researchers suspect.

Building and assembling the multitude was an enormous task. Workers poured clay mixtures into casts of torsos, limbs and other body parts, and then assembled the bodies, taking care to create different facial features for each soldier. Finished statues, now mostly gray, were covered in colored lacquers and likely fired in kilns. Most figures were placed inside one giant pit. Earthen walls formed 11 parallel corridors where statues stood in battle-ready rows.

Still, no workshops or debris firmly linked to the statue-making process have been found. As a result, the number, size, location and organization of workshops involved in producing the emperor’s ceramic troops remain uncertain.

Archaeologist Patrick Quinn of University College London and three Chinese colleagues studied the composition of clay samples from the site. The pieces were taken from 12 terra-cotta warriors, two acrobat statues found in a second pit, five clay bricks from the floor of the largest pit, clay fragments from inside three bronze waterfowl statues found in a third pit and part of an earthen wall in the acrobat pit.

Microscopic analysis of the samples revealed that the clay came from deposits near the tomb’s location, the scientists say. But the recipes for different parts varied. Paving bricks contained only a mixture of dark and light clays, while the clay used for warriors and acrobats had sand worked in. Sand and plant fragments were folded into a clay mixture that formed the core of the bronze waterfowl.
Sand may have made the clay more malleable for shaping into ornate figures and increased statues’ durability, the researchers speculate. Plant pieces may have helped reduce the weight of birds’ clay cores. A clay-processing site at or just outside the emperor’s mausoleum must have doled out the appropriate clay pastes to an array of workshops where potters made statues, bricks or other objects, the scientists propose.

What’s more, many statue and waterfowl samples show signs of having been slowly heated in kilns at maximum temperatures of no more than 750˚ Celsius. That’s lower by 150˚ C or more than some previous estimates, the investigators say. Fires set in an attack on the tomb after the emperor’s death may have refired some of the clay, accounting for the temperature discrepancy, the researchers say.

“I’m not at all surprised by the new findings,” says East Asian art historian Robin D.S. Yates of McGill University in Montreal. Legal and administrative documents previously found at two other Qin Empire sites describe workshops that specialized in various types of craft production, Yates says.

In some cases, artisans’ stamps and inscriptions on terra-cotta warriors match those on excavated roof tiles from Emperor Qin’s mausoleum. The markings suggest that some workshops made several types of ceramic objects, says East Asian art historian Lothar Ledderose of Heidelberg University in Germany. Inscriptions on statues also indicate that artisans working at off-site factories during the Qin Empire collaborated with potters at local workshops to produce the terra-cotta army, Ledderose says.

These transparent fish turn rainbow with white light. Now, we know why

The ghost catfish transforms from glassy to glam when white light passes through its mostly transparent body. Now, scientists know why.

The fish’s iridescence comes from light bending as it travels through microscopic striped structures in the animal’s muscles, researchers report March 13 in the Proceedings of the National Academy of Sciences.

Many fishes with iridescent flair have tiny crystals in their skin or scales that reflect light (SN: 4/6/21). But the ghost catfish (Kryptopterus vitreolus) and other transparent aquatic species, like eel larvae and icefishes, lack such structures to explain their luster.

The ghost catfish’s see-through body caught the eye of physicist Qibin Zhao when he was in an aquarium store. The roughly 5-centimeter-long freshwater fish is a popular ornamental species. “I was standing in front of the tank and staring at the fish,” says Zhao, of Shanghai Jiao Tong University. “And then I saw the iridescence.”

To investigate the fish’s colorful properties, Zhao and colleagues first examined the fish under different lighting conditions. The researchers determined its iridescence arose from light passing through the fish rather than reflecting off it. By using a white light laser to illuminate the animal’s muscles and skin separately, the team found that the muscles generated the multicolored sheen.
The researchers then characterized the muscles’ properties by analyzing how X-rays scatter when traveling through the tissue and by looking at it with an electron microscope. The team identified sarcomeres — regularly spaced, banded structures, each roughly 2 micrometers long, that run along the length of muscle fibers — as the source of the iridescence.

The sarcomeres’ repeating bands, comprised of proteins that overlap by varying amounts, bend white light in a way that separates and enhances its different wavelengths. The collective diffraction of light produces an array of colors. When the fish contracts and relaxes its muscles to swim, the sarcomeres slightly change in length, causing a shifting rainbow effect.
The purpose of the ghost catfish’s iridescence is a little unclear, says Heok Hee Ng, an independent ichthyologist in Singapore who was not involved in the new study. Ghost catfish live in murky water and seldom rely on sight, he says. But the iridescence might help them visually coordinate movements when traveling in schools, or it could help them blend in with shimmering water to hide from land predators, like some birds, he adds.

Regardless of function, Ng is excited to see scientists exploring the ghost catfish’s unusual characteristics.

“Fishes actually have quite a number of these interesting structures that serve them in many ways,” he says. “And a lot of these structures are very poorly studied.”

Ancient DNA suggests people settled South America in at least 3 waves

DNA from a 9,000-year-old baby tooth from Alaska, the oldest natural mummy in North America and remains of ancient Brazilians is helping researchers trace the steps of ancient people as they settled the Americas. Two new studies give a more detailed and complicated picture of the peopling of the Americas than ever before presented.

People from North America moved into South America in at least three migration waves, researchers report online November 8 in Cell. The first migrants, who reached South America by at least 11,000 years ago, were genetically related to a 12,600-year-old toddler from Montana known as Anzick-1 (SN: 3/22/14, p. 6). The child’s skeleton was found with artifacts from the Clovis people, who researchers used to think were the first people in the Americas, although that idea has fallen out of favor. Scientists also previously thought these were the only ancient migrants to South America.
But DNA analysis of samples from 49 ancient people suggests a second wave of settlers replaced the Clovis group in South America about 9,000 years ago. And a third group related to ancient people from California’s Channel Islands spread over the Central Andes about 4,200 years ago, geneticist Nathan Nakatsuka of Harvard University and colleagues found.
People who settled the Americas were also much more genetically diverse than previously thought. At least one group of ancient Brazilians shared DNA with modern indigenous Australians, a different group of researchers reports online November 8 in Science.
Early Americans moved into prehistoric South America in at least three migratory waves, a study proposes. Ancestral people who crossed from Siberia into Alaska first gave rise to groups that settled North America (gray arrows). The first wave of North Americans (blue) were related to Clovis people, represented by a 12,600-year-old toddler from Montana called Anzick-1. They moved into South America at least 11,000 years ago, followed by a second wave (green) whose descendants contributed most of the indigenous ancestry among South Americans today. A third migration wave (yellow) from a group that lived near California’s Channel Island moved into the Central Andes about 4,200 years ago. Dotted areas indicate that people there today still have that genetic ancestry.
Genetically related, but distinct groups of people came into the Americas and spread quickly and unevenly across the continents, says Eske Willerslev, a geneticist at the Natural History Museum of Denmark in Copenhagen and a coauthor of the Science study. “People were spreading like a fire across the landscape and very quickly adapted to the different environments they were encountering.”

Both studies offer details that help fill out an oversimplified narrative of the prehistoric Americas, says Jennifer Raff, an anthropological geneticist at the University of Kansas in Lawrence who was not involved in the work. “We’re learning some interesting, surprising things,” she says.

For instance, Willerslev’s group did detailed DNA analysis of 15 ancient Americans different from those analyzed by Nakatsuka and colleagues. A tooth from Trail Creek in Alaska was from a baby related to a group called the ancient Beringians, who occupied the temporary land mass between Alaska and Siberia called Beringia. Sometimes called the Bering land bridge, the land mass was above water before the glaciers receded at the end of the last ice age. The ancient Beringians stayed on the land bridge and were genetically distinct from the people who later gave rise to Native Americans, Willerslev and colleagues found.

The link between Australia and ancient Amazonians also hints that several genetically distinct groups may have come across Beringia into the Americas.

The Australian signature was first found in modern-day indigenous South Americans by Pontus Skoglund and colleagues (SN: 8/22/15, p. 6). No one was sure why indigenous Australians and South Americans shared DNA since the groups didn’t have any recent contact. One possibility, says Skoglund, a geneticist at the Francis Crick Institute in London and a coauthor of the Cell paper, was that the signature was very old and inherited from long-lost ancestors of both groups.

So Skoglund, Nakatsuka and colleagues tested DNA from a group of ancient Brazilians, but didn’t find the signature. Willerslev’s group, however, examined DNA from 10,400-year-old remains from Lagoa Santa, Brazil, and found the signature, supporting the idea that modern people could have inherited it from much older groups. And Skoglund is thrilled. “It’s amazing to see it confirmed,” he says.

How that genetic signature got to Brazil in the first place is still a mystery, though. Researchers don’t think early Australians paddled across the Pacific Ocean to South America. “None of us really think there was some sort of Pacific migration going on here,” Skoglund says.

That leaves an overland route through Beringia. There’s only one problem: Researchers didn’t find the Australian signature in any of the ancient remains tested from North or Central America. And no modern-day indigenous North or Central Americans tested have the signature either.

Still, Raff thinks it likely that an ancestral group of people from Asia split off into two groups, with one heading to Australia and the other crossing the land bridge into the Americas. The group that entered the Americas didn’t leave living descendants in the north. Or, because not many ancient remains have been studied, it’s possible that scientists have just missed finding evidence of this particular migration.

If Raff is right, that could mean that multiple groups of genetically distinct people made the Berigian crossing, or that one group crossed but was far more genetically diverse than researchers have realized.

The studies may also finally help lay to rest a persistent idea that some ancient remains in the Americas are not related to Native Americans today.

The Lagoa Santans from Brazil and a 10,700-year-old mummy from a place called Spirit Cave in Nevada had been grouped as “Paleoamericans” because they both had narrow skulls with low faces and protruding jaw lines, different from other Native American skull shapes. Some researchers have suggested that Paleoamericans — including the so-called Kennewick Man, whose 8,500-year-old remains were found in the state of Washington (SN: 12/26/15, p. 30) — weren’t Native Americans, but a separate group that didn’t have modern descendants.

But previous studies of Paleoamericans and Willerslev’s analysis of the Spirit Cave mummy’s DNA provide evidence that, despite their skull shapes, the Paleoamericans were not different from other Native Americans of their time. And the ancient people are more closely related to present-day Native Americans than any other group.

Willerslev presented the results about the Spirit Cave mummy to the Fallon Paiute-Shoshone tribe when the data became available. Based on the genetic results, the tribe was able to claim the mummy as an ancestor and rebury the remains.

Do you know how your drinking water is treated?

Disinfection of public drinking water is one of the great public health success stories of the 20th century. In 1900, outbreaks of cholera and typhoid, both caused by waterborne bacteria, were common in American cities. In 1908, Jersey City, N.J., became the first U.S. city to routinely disinfect community water. Other cities and towns quickly followed, and by 1920, the typhoid rate in the United States had dropped by 66 percent.

But that battle isn’t over. Around the world, more than 2 billion people lack reliable access to safe water (SN: 8/18/18, p. 14), and half a million people die each year from diarrhea caused by contaminated water, according to the World Health Organization.
And in the United States, challenges remain. The management failures that caused the 2014 lead contamination crisis in Flint, Mich., were a wake-up call (SN: 3/19/16, p. 8), but Flint is hardly alone. Systems in other big cities are also falling short. In October, officials in Newark, N.J., scrambled to hand out home water filters after it became clear that efforts to prevent lead from leaching into drinking water were not getting the job done. In the first six months of 2017, more than 22 percent of water samples in that city exceeded federal limits for lead, according to news reports.

If big cities are struggling, small towns with skimpy budgets as well as the many people who get their water from private wells often have it harder, lacking access to the infrastructure or technology to make water reliably safe. But science can help.

In this issue, Science News staff writer Laurel Hamers digs into the latest research on water treatment technology and finds a focus on efforts to invent affordable, scalable solutions. There’s a lot of engineering and chemistry involved, not surprisingly, and also physics — it’s hard to move water efficiently through a filter while also catching the bad stuff. Her story is a testament to researcher ingenuity, and a helpful primer on how a typical municipal water treatment plant works.

As I read Hamers’ story, I realized that I didn’t know how our water is treated here in Washington, D.C., even though I live barely a mile from one of the city’s two treatment plants. (I at least get credit for knowing the water comes from the Potomac River.) So I Googled it and found a description of how that process works. Plus I found data on potential contaminants such as Giardia and Cryptosporidium, as well as information on how residents can get their water tested for lead, which can leach from pipes or fixtures.
I also learned that each spring, the Washington Aqueduct briefly switches disinfectants from chloramine to chlorine while the agency cleans the water pipes. That might explain the short-lived swimming pool smell in the tap water.

For me, this became a double win; I learned a lot about advances in water treatment technology from Hamers’ reporting, and I was motivated to seek out information about my local water supply.

If other readers feel inspired by our work to learn more, count me as a happy journalist.

A satellite screw-up reaffirms Einstein’s theory of gravity

An orbital oopsie has led to new proof of Albert Einstein’s physics prowess.

In 2014, two satellites intended for Europe’s Galileo network, the equivalent of the United States’ GPS network, were placed into orbit incorrectly, causing them to travel around Earth in ellipses rather than circles. That wasn’t ideal for the satellites’ originally intended navigational use, but scientists realized the wayward satellites were perfect for another purpose: testing Einstein’s theory of gravity, the general theory of relativity.

According to general relativity, gravity affects not just space, but also time. The deeper within a gravitational field you are, the slower time passes (SN: 10/17/15, p. 16). So a clock at a higher altitude will tick faster than one closer to Earth’s surface, where Earth’s gravity is stronger. The satellites’ orbital mishap allowed the most precise test yet of this effect, known as gravitational redshift, two teams of scientists report in a pair of papers in the Dec. 7 Physical Review Letters.

As the two misplaced satellites move in their elliptical orbits, their distance from Earth periodically increases and decreases by about 8,500 kilometers. Using the precise atomic clocks on the satellites, the scientists studied how that altitude change affected the flow of time. The clocks sped up and slowed down by tiny fractions of a second as expected, agreeing with the predictions of general relativity within a few thousandths of a percent, the teams report.

A second repeating fast radio burst has been tracked to a distant galaxy

SEATTLE — Astronomers have spotted a second repeating fast radio burst, and it looks a lot like the first. The existence of a second repeating burst suggests there could be many more of the mysterious signals in the cosmos.

The burst, called FRB 180814.J0422+73, is one of 13 newly discovered fast radio bursts, or FRBs — brief, bright signals of radio energy that come from distant galaxies. The FRBs were detected over a few weeks last year by the Canadian Hydrogen Intensity Mapping Experiment, or CHIME, in British Columbia. Astronomers reported the discoveries at a meeting of the American Astronomical Society on January 7 and in the Jan. 9 Nature.
Most such bursts erupt once, last for a few milliseconds, and are never seen again. So astronomers have puzzled over what causes them for years (SN: 8/9/14, p. 22).

“If you have something that flashes for a millisecond in the sky, and there’s nothing that happens for many years, it’s really hard to study,” says astronomer Shriharsh Tendulkar of McGill University in Montreal, a member of the CHIME team.

But then in 2016, astronomers discovered the first repeating FRB when they realized that a series of bursts all came from a single source, called FRB 121102 (SN: 4/2/16, p. 12). Astronomers tracked the signal to its host galaxy (SN: 2/4/17, p. 10) and determined it was coming from an extremely magnetic environment, such as the region surrounding a black hole (SN: 2/3/18, p. 6). Researchers didn’t know if FRB 121102’s repeating signal was unique. Of the more than 60 FRBs detected, no other was known to repeat — until now. Having spotted a second one, scientists are searching for more.

“Imagine you saw a unicorn,” Tendulkar says. “Then suddenly you discover another one. You know now there is a population of these. There is hope for discovering a lot more.”
The CHIME team detected the first of the repeating FRB signals on August 14, with four more coming over the next two months from the same spot on the sky. It wasn’t until the third burst, on September 17, that the team realized they might have a repeater, Tendulkar says.

“Somebody pointed out, hey look, these three bursts seem to have the same properties,” he says. “Everybody got really excited.”

Calculations show that the new repeater is about 1.6 billion light-years away. The CHIME team also saw an odd similarity between the two known repeating bursts. Most FRBs are just a sharp blip, akin to a single note being played on a trumpet. But some of the individual bursts in both repeaters were made up of multiple sub-bursts that descended in frequency, like the “wah wah wah wah” of a sad trombone.

“We’ve seen this in 121102, and we can’t explain it,” says astronomer Emily Petroff of ASTRON, the Netherlands Institute of Radio Astronomy, who was not involved in the new work. “Up until now we’ve only had the one repeater, and it’s given us more questions than answers.” But the fact that both repeaters behave similarly could suggest they have similar origins, she says.

Astronomers may have already caught a third repeating burst, too. FRB 110523, discovered in 2015, has some similar features to the first known repeating FRB, so it was worth checking to see if it also repeats, said astronomer Allison McCarthy of the University of Alabama in Tuscaloosa.

Together with Andrew Seymour of the Green Bank Observatory in West Virginia, McCarthy analyzed more than 41 hours of observations of FRB 110523 taken at the Arecibo Observatory in Puerto Rico. They found one potential repeat burst, McCarthy reported January 9 in a poster at the AAS meeting, but they’re not declaring victory just yet. “It wasn’t strong enough for us to be very sure we had detected one,” McCarthy said, adding that they’re about 60 percent certain. “But it’s still a promising candidate.”

Astronomers’ theories for what causes FRBs are almost as numerous as known FRBs themselves. At one point, astronomers even considered the idea that FRBs could be signals from intelligent aliens. But it’s unclear if the repeating bursts and single bursts both come from the same kinds of sources, or even if one-offs might also repeat if watched for long enough.

“It’s the wild, wild west out there,” Tendulkar says. “We have tantalizing clues, but it’s hard to make definitive conclusions.”

CHIME is likely to catch a lot more of these fast radio bursts. The telescope was still being tested when it caught the 13 new ones, so was not operating at peak performance. “They just barely turned on the telescope,” Petroff says, “and they’re already finding things.”

Epileptic seizures may scramble memories during sleep

SAN FRANCISCO — Seizures during sleep can scramble memories — a preliminary finding that may help explain why people with epilepsy sometimes have trouble remembering.

The sleeping brain normally rehashes newly learned material, a nocturnal rehearsal that strengthens those memories. Neuroscientist Jessica Creery and her colleagues forced this rehearsal by playing certain sounds while nine people with epilepsy learned where on a screen certain pictures of common objects were located. Then, while the subjects later slept, the researchers played the sounds to call up some of the associated memories.

This sneaky method of strengthening memories, called targeted memory reactivation, worked as expected for five people who didn’t have seizures during the process. When these people woke up, they remembered the picture locations reactivated by a tone better than those that weren’t reactivated during sleep, said Creery, of Northwestern University in Evanston, Ill. She presented the research March 25 at the annual meeting of the Cognitive Neuroscience Society.

The opposite was true, however, for four people who had mild seizures, detected only by electrodes implanted deep in the brain, while they slept. For these people, memory reactivation during sleep actually worsened memories, making the reactivated memories weaker than the memories that weren’t reactivated during sleep. The combination of seizures and memory reactivation “seems like it’s actually scrambling the memory,” Creery says, a finding that suggests that seizures somehow accelerate forgetting.